Cole Lab

86 entries « 1 of 2 »

2024

Wu, M.; Hanly, A.; Gibson, F.; Fisher, R.; Rogers, S.; Park, K.; Zuger, A.; Kuang, K.; Kalin, J. H.; Nocco, S.; Cole, M.; Xiao, A.; Agus, F.; Labadorf, A.; Beck, S.; Collard, M.; Cole, P. A.; Alani., R. M.

The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma. Journal Article

In: J. Clin. Invest., pp. e171063, 2024.

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Wright, K. M.; S, S. Nathan; Jiang, H.; Xia, W.; Kim, H.; Chakouri, N.; Nwafor, J. N.; Fossier, L.; Srinivasan, L.; Chen, Z.; Boronina, T.; Post, J.; Paul, S.; Cole, R. N.; Ben-Johny, M.; Cole, P. A.; Gabelli, S. B.

NEDD4L Intramolecular Interactions Regulate Its Auto- and Substrate NaV1.5 Ubiquitination. Journal Article Forthcoming

In: J. Biol. Chem., Forthcoming.

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Hagemeister, M.; Hamilton, L.; Wandrey, N.; Hill, M.; Mounce, E.; Mosel, N.; Lytle, K.; Redinger, M.; Boley, J.; Fancher, N.; Haynes, A.; Fill, I.; Cole, P. A.; Hill, E.; Moxley, M. A.; Thomas, A. A.

Evaluation of Rhodanine Indolinones as AANAT Inhibitors Journal Article

In: ChemMedChem, vol. 19, pp. e202300567, 2024.

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Kida, M.; Fatima, I.; Otero-Viñas, E. Rozhkova M.; Wu, M.; Kalin, J. H.; Cole, P. A.; Falanga, V.; Alani, R. M.; Sharov, A. A.

Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration Journal Article

In: J. Invest. Dermatol., vol. 144, pp. 378-386, 2024.

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2023

Wright, K. M.; Jiang, H.; Xia, W.; Murphy, M. B.; Boronina, T. N.; Nwafor, J. N.; Kim, H.; Iheanacho, A. M.; Azurmendi, P. A.; Cole, R. N.; Cole, P. A.; Gabelli, S. B.

The C-Terminal of NaV1.7 Is Ubiquitinated by NEDD4L. Journal Article

In: ACS Bio. Med. Chem. Au, vol. 3, pp. 516-527, 2023.

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Mansur, A.; Joseph, R.; Kim, E. S.; Jean-Beltran, P. M.; Udeshi, N. D.; Pearce, C.; Jiang, H.; Iwase, R.; Milev, M. P.; Almousa, H. A.; McNamara, E.; Widrick, J.; Perez, C.; Ravenscroft, G.; Sacher, M.; Cole, P. A.; Carr, S. A.; Gupta, V. A.

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset Journal Article

In: Elife, vol. 12, pp. e81966, 2023.

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Nardone, C.; Palanski, B. A.; Scott, D. C.; Timms, R. T.; Barber, K. W.; Gu, X.; Mao, A.; Leng, Y.; Watson, E. V.; Schulman, B. A.; Cole, P. A.; Elledge, S. J.

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients Journal Article

In: Mol. Cell, vol. 83, pp. 57-73, 2023.

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Wang, Z. A.; Markert, J. W.; Whedon, S. D.; Yapa-Abeywardana, M.; Lee, K.; Jiang, H.; Suarez, C.; Li, H.; Farnung, L.; Cole, P. A.

Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation Journal Article

In: J. Am. Chem. Soc., vol. 145, pp. 6811-6822, 2023.

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Iwase, R.; Dempsey, D. R.; Whedon, S. D.; Jiang, H.; Palanski, B. A.; Deng, B.; Cole, P. A.

Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination Journal Article

In: J. Am. Chem. Soc., vol. 145, pp. 6039–6044, 2023.

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2022

Lee, K.; Whedon, S. D.; Wang, Z. A.; Cole, P. A.

Distinct biochemical properties of the class I histone deacetylase complexes Journal Article

In: Curr. Opin. Chem. Biol., vol. 70, pp. 102179, 2022.

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Jiang, H.; Chiang, C.; Chen, Z.; Nathan, S.; D’Agostino, G.; Paulo, J.; Song, G.; Zhu, H.; Gabelli, S. B.; Cole, P. A.

Enzymatic Analysis of WWP2 E3 Ubiquitin Ligase Using Protein Microarrays Identifies Autophagy-Related Substrates Journal Article

In: J. Biol. Chem., vol. 298, pp. 101854, 2022.

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Bae, H.; Viennet, T.; Park, E.; Chu, N.; Salguero, A.; Eck, M. J.; Arthanari, H.; Cole, P. A.

PH domain-mediated autoinhibition and oncogenic activation of Akt Journal Article

In: eLife, vol. 11, pp. e80148, 2022.

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Min, D.; Byun, J.; Lee, E. H.; Khan, A. A.; Liu, C.; Loudig, O.; Hu, W.; Zhao, Y.; Herlyn, M.; Tycko, B.; Cole, P. A.; Ryu, B.

Epigenetic Silencing of BMP6 by Sin3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1 Journal Article

In: Mol. Cancer Res., vol. 20, pp. 217-230, 2022.

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Wang, Z. A.; Whedon, S. D.; Wu, M.; Weng, S.; Brown, E. A.; Anmangandla, A.; Regan, L.; Lee, K.; Du, J.; Hong, J. Y.; Fairall, L.; Kay, T.; Lin, H.; Zhao, Y.; Schwabe, J. W. R.; Cole, P. A.

Histone H2B Deacylation Selectivity: Exploring Chromatin’s Dark Matter with an Engineered Sortase Journal Article

In: J. Am. Chem. Soc., vol. 144, pp. 3360-3364, 2022.

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Whedon, S. D.; Cole, P. A.

KATs off: Biomedical insights from lysine acetyltransferase inhibitors Journal Article

In: Curr. Opin. Chem. Biol., vol. 72, pp. 102255, 2022.

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Salguero, A.; Chen, M.; Balana, A.; Chu, N.; Jiang, H.; Bae, H.; Palanski, B. A.; Wright, K.; Nathan, S.; H.Zhu,; Gabelli, S.; Pratt, M.; Cole, P. A.

Multifaceted Regulation of Akt by Diverse C-terminal Post-translational Modifications Journal Article

In: ACS Chem. Biol., vol. 17, pp. 68-76, 2022.

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2021

Shiota, H.; Alekseyenko, A. A.; Wang, Z. A; Filic, I.; Knox, T. M.; Luong, N. M.; Huang, Y.; Scott, D. A.; Jones, K. L.; Gokhale, P. C.; Lemieux, M. E.; Cole, P. A.; Kuroda, M. I.; French, C. A.

Chemical Screen Identifies Diverse and Novel Histone Deacetylase Inhibitors as Repressors of NUT Function: Implications for NUT Carcinoma Pathogenesis and Treatment Journal Article

In: Mol. Cancer Res., vol. 19, no. 11, pp. 1818-1830, 2021, ISSN: 1557-3125.

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Dempsey, D. R.; Viennet, T.; Iwase, R.; Park, E. Y.; Henriquez, S.; Chen, Z.; Jeliazkov, J. R.; Palanski, B. A.; Phan, K. L.; Coote, P.; Gray, J. J.; Eck, M. J.; Gabelli, S. B.; Arthanari, H.; Cole, P. A.

The structural basis of PTEN regulation by multi-site phosphorylation Journal Article

In: Nat. Struct. Mol. Biol., vol. 28, no. 10, pp. 858-868, 2021, ISSN: 1545-9985.

Abstract | Links | BibTeX | Tags: Animals, Ciona intestinalis, Crystallography, Fluorescence Polarization, Humans, Magnetic Resonance Spectroscopy, Molecular Docking Simulation, Phosphorylation, PTEN Phosphohydrolase, X-Ray

Huang, H.; Zhang, D.; Weng, Y.; Delaney, K.; Tang, Z.; Yan, C.; Qi, S.; Peng, C.; Cole, P. A.; Roeder, R. G.; Zhao, Y.

The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway Journal Article

In: Sci. Adv., vol. 7, no. 9, 2021, ISSN: 2375-2548.

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Jiang, H.; Dempsey, D. R.; Cole, P. A.

Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S Journal Article

In: Biochemistry, 2021, ISSN: 1520-4995.

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Jiang, H.; Cole, P. A.

N-Terminal Protein Labeling with N-Hydroxysuccinimide Esters and Microscale Thermophoresis Measurements of Protein-Protein Interactions Using Labeled Protein Journal Article

In: Curr. Protoc. Mol. Bio., pp. e14, 2021, ISSN: 2691-1299.

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Na, M.; Martin, G. M.; Karl, D. L.; Sun, J.; Torres-Martin, M.; Itonaga, H.; Martinez, C.; Chen, S.; Xu, Y.; Duffort, S.; Hamard, P. -J.; Chen, C.; Cimmino, L.; Yang, F. -C.; Zucconi, B.; Cole, P. A.; Xu, M.; Figueroa, M. E.; Nimer, S. D.

P300 Suppresses the Transition of Myelodysplastic Syndrome to Acute Myeloid Leukemia Journal Article

In: JCI Insights, vol. 6, pp. e138478, 2021.

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Pujari, S. S; Wu, M.; Thomforde, J.; Wang, Z. A.; Chao, C.; Olson, N.; Erber, L.; Pomerantz, W.; Cole, P. A.; Tretyakova, N.

Site-specific 5-Formyl Cytosine Mediated DNA-Histone Crosslinks: Synthesis and Polymerase Bypass by Human DNA Polymerase η Journal Article

In: Angew. Chem. Int. Ed., vol. 60, pp. 26489-26494, 2021.

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2020

Hsu, J. W.; Bai, M.; Li, K.; Yang, J. S.; Chu, N.; Cole, P. A.; Eck, M. J.; Li, J.; Hsu, V. W.

The protein kinase Akt acts as a coat adaptor in endocytic recycling Journal Article

In: Nat. Cell Biol., vol. 22, no. 8, pp. 927–933, 2020.

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Chu, N.; Viennet, T.; Bae, H.; Salguero, A.; Boeszoermenyi, A.; Arthanari, H.; Cole, P. A.

The Structural Determinants of PH Domain-Mediated Regulation of Akt Revealed by Segmental Labeling Journal Article

In: Elife, vol. 9, 2020.

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Wang, Z. A.; Cole, P. A.

The Chemical Biology of Reversible Lysine Post-translational Modifications Journal Article

In: Cell Chem. Biol., 2020.

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Morrison-Smith, C. D.; Knox, T. M.; Filic, I.; Soroko, K. M.; Eschle, B. K.; Wilkens, M. K.; Gokhale, P. C.; Giles, F.; Griffin, A.; Brown, B.; Shapiro, G. I.; Zucconi, B. E.; Cole, P. A.; Lemieux, M. E.; French, C. A.

Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734 Journal Article

In: Mol. Cancer Ther., vol. 19, no. 7, pp. 1406–1414, 2020.

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Wang, Z. A.; Millard, C. J.; Lin, C. L.; Gurnett, J. E.; Wu, M.; Lee, K.; Fairall, L.; Schwabe, J. W.; Cole, P. A.

Diverse nucleosome Site-Selectivity among histone deacetylase complexes Journal Article

In: Elife, vol. 9, 2020.

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Cole, P. A.; Shapiro, T.

Paul Talalay 1923-2019 A Biographical Memoir Journal Article

In: National Academy of Sciences, 2020.

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Jiang, H.; D’Agostino, G. D.; Cole, P. A.; Dempsey, D. R.

Selective protein N-terminal labeling with N-hydroxysuccinimide esters Journal Article

In: Methods Enzymol., vol. 639, pp. 333–353, 2020.

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Mattevi, A.; Cole, P. A.

Editorial Overview: Biological catalysis at the cross-roads of signaling and metabolism Journal Article

In: Curr. Opin. Struct. Biol., vol. 59, pp. iii-iv, 2020.

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Xiong, Y.; Wang, L.; Giorgio, E. D.; Akimova, T.; Beier, U. H.; Han, R.; Trevisanut, M.; Kalin, J. H.; Cole, P. A.; Hancock, W. W.

Essential Role of the CoREST Complex in Foxp3+ T-Regulatory Cell Functions Journal Article

In: J. Clin. Invest., vol. 130, pp. 1830-1842, 2020.

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Song, Y.; Dagil, L.; Fairall, L.; Robertson, N.; Wu, M.; Ragan, T. J.; Savva, C. G.; Saleh, A.; Morone, N.; Kunze, M. B. A.; Jamieson, A. G.; Cole, P. A.; Hansen, D. F.; Schwabe, J. W. R.

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex Journal Article

In: Cell Rep., vol. 30, pp. 2699-2711, 2020.

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Miller, S. A.; Policastro, R. A.; Savant, S. S.; Sriramkumar, S.; Ding, N.; Lu, X.; Mohammad, H. P.; Cao, S.; Kalin, J. H.; Cole, P. A.; Zentner, G. E.; O’Hagan, H. M.

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer Journal Article

In: Mol. Cancer Res., vol. 18, no. 2, pp. 264–277, 2020.

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Wang, Z. A.; Cole, P. A.

Methods and Applications of Expressed Protein Ligation Journal Article

In: Methods Mol. Biol., vol. 2133, pp. 1–13, 2020.

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2019

Jiang, H.; Thomas, S. N.; Chen, Z.; Chiang, C. Y.; Cole, P. A.

Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases Journal Article

In: J. Biol. Chem., 2019, ISSN: 1083-351X.

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de Velde, S. V.; Wiater, E.; Tran, M.; Hwang, Y.; Cole, P. A; Montminy, M.

CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers Journal Article

In: Mol. Cell Biol., vol. 39, no. 17, 2019, ISSN: 1098-5549.

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Henager, S.; Henriquez, S.; Dempsey, D. R.; Cole, P. A.

Analysis of Site-specific Phosphorylation of PTEN using Enzyme-Catalyzed Expressed Protein Ligation Journal Article

In: ChemBioChem, 2019, ISSN: 1439-7633.

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Kim, E.; Zucconi, B. E.; Wu, M.; Nocco, S. E.; Meyers, D. J.; McGee, J. S.; Venkatesh, S.; Cohen, D. L.; Gonzalez, E. C.; Ryu, B.; Cole, P. A.; Alani, R. M.

MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma Journal Article

In: Cancer Res., vol. 79, no. 10, pp. 2649-2661, 2019, ISSN: 1538-7445.

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Zucconi, B. E.; Makofske, J. L.; Meyers, D. J.; Hwang, Y.; Wu, M.; Kuroda, M. I.; Cole, P. A.

Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP Journal Article

In: Biochemistry, vol. 58, no. 16, pp. 2133-2143, 2019, ISSN: 1520-4995.

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Liu, Yujie; Bao, Chunrong; Wang, Liqing; Han, Rongxiang; Beier, Ulf H; Akimova, Tatiana; Cole, Philip A; Dent, Sharon Y R; Hancock, Wayne W

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells Journal Article

In: Cancers (Basel), vol. 11, no. 4, 2019, ISSN: 2072-6694.

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Cole, Philip A; Chu, Nam; Salguero, Antonieta L; Bae, Hwan

AKTivation mechanisms Journal Article

In: Curr Opin Struct Biol, vol. 59, pp. 47-53, 2019, ISSN: 1879-033X.

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Anastas, Jamie N; Zee, Barry M; Kalin, Jay H; Kim, Mirhee; Guo, Robyn; Alexandrescu, Sanda; Blanco, Mario Andres; Giera, Stefanie; Gillespie, Shawn M; Das, Jayanta; Wu, Muzhou; Nocco, Sarah; Bonal, Dennis M; Nguyen, Quang-De; Suva, Mario L; Bernstein, Bradley E; Alani, Rhoda; Golub, Todd R; Cole, Philip A; Filbin, Mariella G; Shi, Yang

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIP Journal Article

In: Cancer Cell, 2019.

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Jiang, Hanjie; Thomas, Stefani N.; Chen, Zan; Chiang, Claire Y.; Cole, Philip A.

Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases. Journal Article

In: J Biol Chem, 2019.

Abstract | Links | BibTeX | Tags:

Cole, P. A.; Mattevi, A.

Editorial overview: Biological catalysis at the cross-roads of signaling and metabolism Journal Article

In: Curr. Opin. Struct. Biol., vol. 59, pp. iii-v, 2019.

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Miller, Michelle S; Maheshwari, Sweta; Shi, Wuxian; Gao, Yuan; Chu, Nam; Soares, Alexei S; Cole, Philip A; Amzel, L Mario; Fuchs, Martin R; Jakoncic, Jean; Gabelli, Sandra B

Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II Journal Article

In: Molecules, vol. 24, no. 3, 2019, ISSN: 1420-3049.

Abstract | Links | BibTeX | Tags: Crystallography, Models, Molecular, Phosphatidylinositol 3-Kinases, Protein Conformation, Proteins, Pyrophosphatases, X-Ray

Kalin, J. H; Eroglu, A.; Liu, H.; Holtzclaw, W. D.; Leigh, I.; Proby, C. M.; Fahey, J. W.; Cole, P. A.; Dinkova-Kostova, A. T

Investigation into the Use of Histone Deacetylase Inhibitor MS-275 as a Topical Agent for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma in an SKH-1 Hairless Mouse Model Journal Article

In: PLoS One, vol. 14, no. 3, pp. e0213095, 2019, ISSN: 1932-6203.

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2018

Bhat, Shridhar; Hwang, Yousang; Gibson, Matthew D; Morgan, Michael T; Taverna, Sean D; Zhao, Yingming; Wolberger, Cynthia; Poirier, Michael G; Cole, Philip A

Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action Journal Article

In: J Am Chem Soc, vol. 140, no. 30, pp. 9478-9485, 2018, ISSN: 1520-5126.

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Lasko, Loren M; Jakob, Clarissa G; Edalji, Rohinton P; Qiu, Wei; Montgomery, Debra; Digiammarino, Enrico L; Hansen, T Matt; Risi, Roberto M; Frey, Robin; Manaves, Vlasios; Shaw, Bailin; Algire, Mikkel; Hessler, Paul; Lam, Lloyd T; Uziel, Tamar; Faivre, Emily; Ferguson, Debra; Buchanan, Fritz G; Martin, Ruth L; Torrent, Maricel; Chiang, Gary G; Karukurichi, Kannan; Langston, J William; Weinert, Brian T; Choudhary, Chunaram; Vries, Peter; Kluge, Arthur F; Patane, Michael A; Drie, John H Van; Wang, Ce; McElligott, David; Kesicki, Edward A; Marmorstein, Ronen; Sun, Chaohong; Cole, Philip A; Rosenberg, Saul H; Michaelides, Michael R; Lai, Albert; Bromberg, Kenneth D

Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours Journal Article

In: Nature, vol. 558, no. 7710, pp. E1, 2018, ISSN: 1476-4687.

Abstract | Links | BibTeX | Tags:

Wu, Mingxuan; Hayward, Dawn; Kalin, Jay H; Song, Yun; Schwabe, John W R; Cole, Philip A

Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex Journal Article

In: Elife, vol. 7, 2018, ISSN: 2050-084X.

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86 entries « 1 of 2 »